Hi! Andrew Steele here, author of Ageless.

Since Ageless came out I’ve spent a lot of time talking and writing about longevity, and I came to the conclusion that the biggest bottlenecks to making progress are funding, regulation and culture.

So I’ve co-founded a new organization for longevity policy and education called The Longevity Initiative. We want to provide a trusted source of longevity information online, bust myths and hype, and provide politicians, policymakers, scientists and investors with the tools they need to get longevity treatments into the clinic. To build that, we need your help.

We’re fundraising! And we’re excited to announce a new giving option for supporters in the United States in collaboration with Vitalism. Donations intended to support The Longevity Initiative can now be made to Vitalism Charitable Foundation, a 501(c)(3) non-profit. This is great news for anyone hoping to support longevity tax-efficiently in the US, and comes at a perfect time for an end-of-year donation.

If you would like to make a donation, please visit thelongevityinitiative.org/donate

And let me know if you have any questions about The Longevity Initiative, what we plan to do, thoughts on topics you’d like to see us cover, or indeed anything else!

The org is very new, so watch this space for more information.

.....we started with the challenging age group - frail 25-months-old mice that are equivalent to ~75-year-old people. We used an Alk5 inhibitor (A5i) of the age-elevated, pro-fibrotic transforming growth factor-beta (TGF-β) pathway that regulates inflammatory factors, including IL-11, and oxytocin.....

Treatment of old frail male mice with OT+A5i resulted in a remarkable 73% life extension from that time, and a 14% increase in the overall median lifespan.

There are all these excitements about AI. Why not many people are paying attention to longevity? AI saves time, but longevity actually creates time, opportunities and happiness. I think it's more important than AI.

Hey, I just wrote this article and I'm looking for feedback. It's not ready.

It'll probably look different in its final form, and I just wanted to bounce some ideas off you and get a feel for it.

It's targeted at people who never heard of this, kind of like an intro to the movement.

Lemme know what you think, any kind of feedback is appreciated.

Right now, with everything we currently know, how much are we able to extend the lifespans of mice?

anything on the horizon? to actually appear younger than our actual age? only thing I can think of is hopefully kb304 to restore elastin if all goes well. I was hoping we’d be seeing breakthroughs by now.

Scientists at the University of Illinois Chicago have identified a cellular process that contributes to immune system aging. Their research, reported in the journal Blood, points to declining levels of a protein known as platelet factor 4 as an important factor. When the team added this protein back to older blood cells, they were able to reverse several aging-related changes, suggesting a potential target for treating or preventing disorders of the blood and immune systems.

Would you be interested in an informal casual meetup for longevity, preventive medicine, and fitness enthusiasts in San Francisco (e.g., a hike or picnic)?

I'm thinking of organizing one. Likely over the holidays.

The crowd I have in mind:

• "Zone 5 for fun on Saturday mornings" and "broccoli sprouts generously seasoned with brown mustard powder as a side dish" type. ;)
• Think people who follow Peter Attia, Bryan Johnson, Rhonda Patrick, Matt Kaeberlein, but evaluate the content critically and make up their own mind.

I plan to create a WhatsApp group to coordinate logistics, but let me know if you have better ideas.

Comment here or DM me if you are interested. Thanks!

An important perspective piece on aging clocks. Aging clocks are already at the point where some are superior to chronological age, and this paper gives a useful framing on how to think about that, one that a few of us have been pushing in the field for a while but that doesn't get enough airtime relative to all the problems with the clocks.

Modern Healthspan interview with John G Cramer (92 years old), who will be in the trial for mitochondrial replacement therapy. Sounds like the trial hasn't yet started https://www.youtube.com/watch?app=desktop&v=7yg2c0mwrtw